Pr. Régis Josien, Director
Dr. Sophie Brouard, Deputy-Director
The CRTI is a joint research unit (UMR 1064) created by INSERM and Université de Nantes in 2012 and renewed in 2017, and is historically the evolution of previous units devoted to transplant immunology for almost 20 years in Nantes. The CRTI is located at the CHU Nantes Hotel Dieu where it constitutes with several clinical departments the Institute of Transplantation Urology and Nephrology (ITUN), one of the largest French and European kidney transplantation centers. This unique environment fosters interactions between basic scientists and clinicians, and explains the strong commitment of the CRTI to translational research.
The CRTI gathers researchers and clinicians with expertise in basic immunology, transplantation, autoimmunity, inflammation, virology, nephrology, regenerative medicine, genetic and bioinformatics and who develop innovative projects going from basic to clinical research. The main and long-term objectives of these project are to improve treatments and patient monitoring in transplantation and immune-mediated inflammatory diseases (IMIDs) through understanding immune responses, developing new immunotherapeutics, biomarkers and tools for personalized medicine and developing alternative strategies for organ or tissue replacement.
The CRTI is organized in 5 independent teams, including an ATIP-Avenir team and 11 core facilities, in which 34 scientists and a total of 170 people currently work to promote research, education and clinical developments.