Regulatory T cells have been described as being capable of inducing tolerance to allogeneic organs, however, CD8+ Treg, while demonstrated as crucial in some diseases, have been put aside and their role and potential in tolerance remain unclear. My projects investigate both in rodent and human antigen-specific regulatory CD8+ T lymphocytes, their biology at a cellular and molecular level, their generation upon encounter with an antigen and their role in transplantation tolerance and autoimmunity. These aspects are particularly important in current transplantation since new immunosuppressive strategies are based on the generation of a donor-specific tolerance. Our long term goals are to allow the establishment of new strategies of tolerance induction and better prognosis/diagnosis of patients before and after transplantation.
- Molecular characterization of CD8+ Tregs: phenotype, function
- Characterization of CD8+ Tregs specificity: Characteristics and roles of the TCR/MHC/peptide interaction in rat and human
- In vivo evaluation of CD8+ Tregs contribution in experimental and human transplantation: CD8+CD45RClow Tregs as a cellular therapy
- Immunotherapy using anti-CD45RC mAbs, allowing to deplete CD4+ and CD8+ effector T cells without affecting CD4+ and CD8+ Tregs
- Immunotherapy using the IL-34 cytokine to induce M2 macrophages and favor tolerance
- Generation of Tregs from induced pluripotent stem cells
2020-2023 // European Joint Programme on Rare Diseases TARID "Thymic Abnormalities in Rare Immunological Diseases" which will aim to study two rare diseases (myasthenia gravis and polyendocrine autoimmune syndrome type 1) which have as common characteristic an inherited or acquired defect in the Autoimmune Regulator gene (AIRE ). This project is the winner of the 1st European Joint Program on Rare Diseases (JTC 2019) call, which funds projects aimed at accelerating the diagnosis and / or exploring the progression and mechanisms of rare diseases.
2019-2022 // We are partners of the H2020 RESHAPE Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cells
2019 // Prize from Fondation Grand Ouest
2019 // 20rd laureate prize from Beatrice Denys Foundation
09-12-16 // We have recently signed out-licensing global agreement with TxCell, a biotechnology company developing innovative, personalized cellular immunotherapies using regulatory T cells, for use of CD8+ Tregs to treat inflammation and autoimmune disorders
09-03-17 // Carole Guillonneau laureate Prize «Don de vie-don de soi» Fondation du Rein 2017
13-06-16 // Carole Guillonneau laureate Prize France Transplant 2016
02-04-16 // Carole Guillonneau (Mentor) and Séverine Bézie (Mentee) receive the 2016 TTS-SFT International Transplantation Science Mentee-Mentor Award